In older people, This is certainly important to comprehend as polypharmacy is frequent and will potentiate the risk of DDIs and ADRs. Therefore, concurrent intake of CYP2D6 inhibitors or inducers could potentiate or block tramadol conversion into ODT and This might raise or minimize efficacy/ADRs from the prescribed tramadol. https://hemalchem.com/product/o-dsmt/