Codeine has long been described to show no proof of carcinogenicity or mutagenicity in many different exam systems, such as the micronucleus and sperm abnormality assays as well as the Salmonella assay. Promethazine was nonmutagenic from the Salmonella examination system of Ames. benzhydrocodone/acetaminophen and codeine both of those improve sedation. https://wockusa.com/product/akorn-promethazine-hydrochloride-and-codeine-phosphate-solution/